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![]() ![]() Also, these experiments suggest that the nucleotide exchange factors (NEFs) HSP110 or its close homolog APG2 are able to support HSP70 disaggregation activity by promoting ADP release and re-binding of ATP, which causes substrate release 24, 26, 28, 29, 30.Īlthough, traditionally, protein aggregation has been seen as an uncontrolled process in cells, many cellular factors have been identified as responsible for modulating the aggregation process 11, 31, 32. The J-domain proteins DJA2 and DJB1 are thought to cooperate to bind the aggregates, recruit HSP70 and stimulate its ATP hydrolysis and substrate polypeptide binding 24, 26, 28, 29. Previous work has shown that in humans and other metazoans, the chaperone HSP70 together with its co-chaperones DNAJB1 (DJB1), DNAJA2 (DJA2) and HSP110/APG2 are capable of disaggregation 24, 25, 26, 27, 28. Disaggregation performed mainly by molecular chaperones, likely the fastest process, is generally followed by protein refolding or proteasomal degradation 12, 21, 22, 23. In order to cope with these aggregates, cells have developed different strategies 11, 12, including compartmentalization into aggresomes followed by autophagy 13, 14, 15, secretion to the extracellular environment 16 and disaggregation (or resolubilization) 17, 18, 19, 20. Therefore, we propose that a human sHSP is an integral part of the chaperone network for protein disaggregation. HSPB1 itself was also extracted during disaggregation, and its homo-oligomerization ability was not required. ![]() Importantly, co-aggregation promoted the efficient disaggregation and refolding of the substrates, led by HSP70. The co-aggregates formed with HSPB1 were smaller and more regularly shaped than those formed in its absence. HSPB1 co-aggregated with unfolded protein substrates, firefly luciferase and mammalian lactate dehydrogenase. Because it is unknown whether a human sHSP has this activity, we investigated the disaggregation role of human HSPB1. The co-aggregated sHSPs then facilitate downstream disaggregation by HSP70. Yeast and bacterial chaperones of the small heat-shock protein (sHSP) family can bind substrates at early stages of misfolding, during the aggregation process. To eliminate aggregates, the HSP70 chaperone machinery extracts and resolubilizes polypeptides for triage to refolding or degradation. ![]() In human cells under stress conditions, misfolded polypeptides can form potentially cytotoxic insoluble aggregates. ![]() ![]() Maxwell for SketchUp Brings you advanced Maxwell Render technology in a. V-Ray for Sketchup Plugin for faster rendering, better lighting tools, and the ability to create and visualize complex scenes. If you are short in time, consider to contribute with a donation to enable us to develop a next version. LumenRT E-on software plugin for the visualization of architectural projects in real-time 3D with photorealistic illumination. After all, the Pro Solid Tools did not exist yet, and no one even knew. This tool provided an inexpensive way to perform some basic boolean operations and worked with both SketchUp Make (free) or Pro. ![]() ![]() Now get active! Contribute ideas, report issues, help to improve the documentation and correct and extent the localizations. About 20 months before SketchUp Pro 8 released the Solid Tools, (way back in Dec 2008), the original BoolTools plugin for SketchUp was released. We would like to thank especially the ones on the growing list of those that are supporting this project regularly: Tom Husband, Michael Kane, David Austin, Steven Kelleher, Philip Sowels, Flint Orr, Frans Goddijn, Manuel ( Caffè Terzi), Richard ( Free Space Coffee), Adam Glass, Steven Olock, Michel ( The Beautiful Bean), Mark ( Velvet Sunrise Coffee Roasters), Graham Kennedy, Hermann-Josef Fensky, Paolo ( His Majesty the Coffee), Nicolas Bigler, Rick Groszkiewicz, Colin ( Iron Mule & Ironside Roasting), Stephen M Egge, and Richard Unger. Efraim Eygin, Jim, Тихонов ( caffeevita), 王彥元, Ernesto Carlos Bode, Cathy & Ernie ( Borrowed Land Farm), 大黒洋 ( 96cafe Roastery), Khin Men Cheah, Nico Damanik, Ron ( VortX), Marc Boer, Matt Keebler, Tawney Buttler, Morgan ( Landmark Speciality Coffee Ltd), Robert Denson, Javier Negron, Don Stewart Morgan, Julie Lund, Shannon Conner, William Malatesta, Ron ( Tangram Coffee Roasters), Barry Regehr, MOJO FOOD TRUCK LLC, Aleksi Rintanen, Milorad Popadic, Dalton Moody, Kyle Grella, Jon Gutierrez, Darren ( Dark Star Coffee Roasters), Matt ( Happy Mug Roasters), Dustin ( Stout Heart Coffee), Jean-Francois Jutras, Rob ( Hoos Coffee Consulting LLC, Jeff Kinzli, Kent ( Freeport Coffee Roasting), Sava Vrbaski, Brian McHenry, Josh Greenberg, Kenneth A Fox, Milorad Popadic, Ina Quilling, Eric Gingras, Todd Trebuna, Chip ( Radio Roasters LLC), Tomohiro Fukitani, Robert Rings, Daniel Burris, Gemma ( Turning Point Coffee), Jane Lau, Thomas Wright, Minuto Coffee, Henrik Haaning, Norman Hardy, Vladimir ( Sputnik Roasters), พลกฤษณ์ โสเจยยะ, Masaharu Kuriya, Ondrej Boucek, BeechCreek Coffee Roasters, Peter Budenz, John Tull, Martin ( Appalaches Torréfacteur), Eric Totong, and Norman Kuckert. ![]() The following individuals and operations (in no specific order) did support the development of this version with their donation to cover the remaining 6% of the development costs: Alan Friedman, Raphael Aschmann, Ronaldo Martins. ![]() ![]() First, select pairs that are blocking the greatest number of other tiles. Next, plan your moves ahead as far as possible and see which open pairs it is best to eliminate to free up new pairs. Look ahead: study the whole board before making your first move and try to identify as many matching pairs as possible. Our game always has at least one solution, so every Mahjong puzzle can be solved. But if you apply the right strategies, you will see that you can solve the puzzle more often and more quickly. It is often assumed that winning at Mahjong is all about luck. Use this option if you have made a mistake or want to see what is under another tile. Undo: you can use Undo at any time to go back one step.But beware that the hint may not be the best move it is usually the first available open pair that the game finds. Hint: if you cannot see any matching pairs, you can use the hint tool to generate a suggestion.Mix: shuffles all the tiles so that they end up in different positions and new pairs become available. ![]() ![]() There are also a few tools available to help you play: The tools The game will then automatically mix the tiles, so you can continue playing. Sometimes, you will not be able to match any more tiles, this can happen if there are two paired tiles on top of one another the bottom tile will then not be visible and cannot be selected. This gets easier as the game progresses, as there are fewer and fewer tiles available and fewer open pairs to search for. You continue matching and eliminating tiles until you have cleared the board. However, you can see that one of them has another tile on top of it, so it cannot be removed. Line 4 points to two tiles that are each free on one side. To be able to remove it, you first need to eliminate the adjacent tiles. If you look at line 3, you can see that only one tile is free, the other tile is blocked by two other tiles and so it cannot be selected. It’s a different story with the tiles indicated by the red lines. The tiles indicated by line 2 are also free on one side, so they can be eliminated as well. If you trace the green line 1 in the picture above, you can see that both of these tiles are free on at least one side, this means these tiles can be combined and eliminated. You can only remove a tile if it is free on at least one side.A tile cannot be selected if it has other tiles on either side of it.A tile can only be selected if there are no other tiles on top of it.You can only combine tiles that meet the following conditions: Instead, you need to match the tiles in the series, such as summer and spring or autumn and winter.Īccording to the rules of Mahjong, it’s not possible to simply match and eliminate any tile that appears on the board. There are 4 tiles in each of these series, all of which only appear once in each game, so it is not possible to match them precisely. There are two exceptions: the flowers series and the seasons series. In other words, you are looking for two pairs in each series. The goal of Mahjong is to combine the tiles with matching images. If you look carefully, you’ll see that some of them are exactly the same, this is because each image appears 4 times in the game. The tiles all have different characters and images on them. When you start, the Mahjong Solitaire game appears as a board with 144 tiles arranged on top of one another in the shape of a pyramid. The Mahjong game has two different versions: the traditional Asian version, which is a game for 4 players, and Mahjong Solitaire, which is always played by one person and is mostly popular in the West, this is the game you can play online on. ![]() ![]() ![]() Avoid light colors such as yellow and pastel colors, as it is not ideal for scanning.ĭarker colors and a white background are an ideal color combination 2. One rule of thumb is to make the foreground color darker than the background color of your QR code. Moreover, do away from inverting your QR code colors. Note: Make your QR code stand out as possible but do not compromise the scan-ability of your QR code. Steer away from black-and-white QR code as it does not get the many results you desire.Ĭustomize your QR code and add colors, set unique edges, choose the patterns, and your preferred layout to make it more appealing. Make a visual QR code using a multi QR code generator, and make sure it leaves a lasting impact on your potential scanners once they see it. We are visual beings, and we usually make a second turn to something that stimulates those senses. This video below explains in-depth details about multi URL QR codesĬustom-designed Multi URL QR codes pique your target audience’s curiosity. This allows you to understand your target audience for robust marketing. Tracking your QR code scans unlocks the demographics of your QR code scanners. Adding a link to a video QR code is also possible for your campaign. Moreover, the URLs that you can add are not limited to websites or landing pages only. You can add/edit/remove URLs in your QR code with multiple links anytime you want and you can also track your QR code scans in real-time. These codes are designed as per your choice and desire. ![]() This type of QR code is made particularly for businesses who want to run campaigns on a worldwide scale and market multiple products, goods, services, websites to different types of audiences around the globe.Ī QR code software with a logo can provide you with a dynamic solution, allowing you to create one QR code for multiple links. If a person scans in China, he will be redirected to a Chinese webpage, or if the user scans in Brazil, he will land to a Brazilian website. Remember, that there should only be one QR code per Multi URL QR code feature.įor example, if you make a QR code with a multiple language feature, you can redirect scanners to a specific landing page based on his language. It's a dynamic QR code solution that can embed different links or URLs in one QR code, which can be used to guide and redirect users based on certain conditions as mentioned above, such as: time, location, number of scans, language, and geofencing. Create your Multi URL QR code for multiple actions with QR TIGERĪ Multi QR code generator lets you create one QR code for multiple links.5 Best Practices when making your Multi URL QR code and get the most out of it.A multi URL QR code redirects to different apps based on iOS or Android Multi URL QR code number of scans redirection Multi URL QR code for language redirection Multi URL QR code for location redirection What are the main features of a Multi-URL QR code?. ![]() ![]() ![]() While not as comprehensive as those in Toon Boom Harmony, where you have access to a multiplane or 3D camera, FlipBook has enough tools for most. 19.99 to download from the Digicel website (This 2D/hand drawn software help you to learn the process of animating your own drawings/creations into movement following the principles of animation) FlipBook 6 is a professional level, hand drawn animation software used in major studios. You can step back and forth through the frames you've shot and then right into the live frame to see exactly how it's going to look added on to the end of the scene so you know what you're going to get, and you get what you want. Like most 2d animation programs, Digicel’s FlipBook program has good camera tools, allowing you to do basic pans, zooms, and rotations, along with blurs to give the illusion of depth of field. You can even use it to combine 2D, 3D and live action.įlipBook is great for stop motion too. ![]() It will help you breakdown your dialog for perfect lip sync. You can use FlipBook to experiment with different timing for sketches of your key frames without having to wait for rendering. Digicel FlipBook helps in creating traditional frame-by-frame animation. Developed by DigiCel, FlipBook runs on both Windows and macOS. DigiCel FlipBook is considered one of the easiest 2D animation software on the market. Its flipbook offers great features for 2D animation such as drawing. You can do a lot of things with this animation software although it is intended for beginners. DigiCel provides easy to learn and use platform for making your own digital publication. Other programs may be OK if all you want to do is ink & paint but animators use FlipBook.įlipBook can also help you do 3D animation. This 2D animation software is easy-to-use but don’t let the simplicity fool you. That's why professional animators at every major studio and teachers at the best animation schools demand FlipBook. Klasky-Csupo was the first studio to pick up FlipBook during production of The Wild Thornberrys. When choosing a 2D animation program for an older or underpowered computer, there are a few key factors to consider: Low System Requirements Look for software specifically made for low-spec PCs, often indie or open source options. Whether you want to do 2D, 3D or Stop Motion Animation, DigiCel FlipBook Makes Animation Easier! FlipBook is the only 2D animation software designed from the ground up to do 2D animation the way animators want to do it. Digicel Flipbook What to Look for in 2D Animation Software. ![]() ![]() After that, head to the Stardew Valley Nexus Mods page and look for the mods you want.Ĭheck out our full guide on how to install mods for more in-depth information:īack to top of FAQ How to get married/how to have children First, you'll need to install the SMAPI installer. It's fairly simple to install mods, but you'll only be able to do so if you are playing on PC. To attach bait, select it in your inventory, and "place" it on your fishing rod in your inventory with the 'use item' button (right-click on PC, Y on Switch, et cetera - whichever button you'd typically use to use a tool, with the exception of PC).īack to top of FAQ How do you install mods? All you need is the fiberglass rod, which is the first upgrade you unlock at Fishing Level 3. Additionally, you'll unlock tackle that can be attached to the iridium rod that will change how the minigame functions, making it easier.įor bait, it's very simple. Don't worry - the size of the bar increases as your Fishing skill levels up. You might find it very hard to keep the fish inside the little green bar. If you can keep the bar on the fish icon long enough as it moves around, the meter will fill up and you'll catch the fish.While it's outside of the bar, the meter will fall. While the fish icon is inside the bar, the meter will fill up. When you press the button, the bar will go up, when you let go, it falls. The small fish icon will move around, and you'll need to press the same button as before to keep that little green bar even with the fish. Press the use tool button (left mouse on PC, Y on Switch, et cetera) to hook the fish when you feel the vibration, hear the noise, and/or see the exclamation mark.After your bobber is in the water, there will be a short time (usually a few seconds), and you may feel a fish bite. There will be a bar that goes up and down, which determines the power of your cast when you press the use tool button again. Cast your line into the water by using the use tool button.Don't worry! It will get easier the more you practice and as you progress through the game. One of the biggest issues that new players face is the extremely difficult fishing minigame in Stardew Valley. How to fish and how to use bait in Stardew Valley How to get married/How to have children?.The Farm Cave: Should You Pick Bats Or Mushrooms?. ![]() The Best and Worst Crops for Each Season:.Specialty Chicken Guides: Blue Chickens | Void Chickens | Golden Chickens.Every Artisan Good And What It Sells For.Regardless, here's everything you'll need to know to build up over the next couple of seasons or years. There are a ton of options available to choose from, or you could do a bit of everything. Do you want to become a truffle oil tycoon, or do you want to start establishing a vineyard? Perhaps you want to grow a bunch of tea leaves or fruit trees. After you've nailed down the basics and established yourself and your farm, you'll most likely want to start building up your machinery, farm buildings, and even potentially deciding on a specialization. ![]() ![]() ![]() It looks slick as hell, is mobile-friendly, and would be useful virtually or face-to-face. It's still in development (go over to r/ShadowrunKit), and the dev is eagerly accepting feedback. I've also found SRKit to be a useful repository for characters. It's not hard to double-check and fill in any gaps. You can export the character to a JSON file Roll20's SR5 sheet has an Import function, where you copy-paste the JSON text and it'll translate it into a filled-in sheet, probably 90% accurate. I've used Chummer to make the characters, like most people. eWkn did the linked portrait above of Ale & Wail.Notesz is our go to for Shadowrun portraits.Alex Carmichal has some great 'totally' not Shadowrun tokens.Nick G for guns, grenades, post-apoc landscapes, tokens.Brass Badger office building, modern roads, post-apoc roads.We commissioned her to do our runner bar, Ale & Wail.Status Effects api is useful if you feel like manually setting up the whole thing for Shadowrun.Character Sheets lets players create their own character sheets.This is what I was using before wring it in the Shadowrun API Group Init can be setup for Shadowrun.I used it for immunity (harden armor) & destroying barrier rules Note: I broke the API last patch, 7 April 2020. Roll initiative for all selected tokens.Add an initiative pass/combat round tracker.Shadowrun 5th Edition API can be used to:.NPC sheets will make your combats faster.Rather crappy video I made on how to use that as well as the Character Sheets api below. Character Vault is useful for keeping backups and moving characters between tables.Grenades, AoE spells, and other items can use a character sheet with a default token to allow players to drag it to the map to see the effect areas. The pieces used here from from Chibbin Grove Create a Dashboard to let players make notes."Watch your back, shoot straight, conserve ammo, and never, ever, cut a deal with a dragon." Living Community (Where you can play online) Subreddits For that please check out /r/ShadowrunReturns for help. Sadly our nova hot community isn't the best place to discuss the mechanics discussion or troubleshooting the video games. Mostly the pen and paper role playing game, but also the deck building card game, video games, and literature of Shadowrun. Discussion is primarily aimed at exploring narratives found in the Sixth World. Here at /r/Shadowrun we talk shop about all things in the shadows. ![]() ![]() ![]() Now You will Select The button you want to use for. Now For Space Drag that is in the 'Motion' action set, make sure you have that tab selected (it should be the default one). You should Now Have a Window similar to This open. This works, and it eliminates the need for Playspace Mover entirely since OVR Advanced Setting now has that ability. The shortest way To get to the Menu is to hit the Bindings Button This is on the front page of OVR Advanced Settings. To reset your playspace, what I did was head over to OVR settings and selected Space Fix, then selected the Revert option at the bottom. Save bindings and you should be able to move your playspace.Edit your bindings to where you could use Space Drag (For example, on Oculus CV1 controllers, I set A/X for Space Drag on button press).Look for "OVR Advanced Settings" or "Advanced Settings" in the bindings tab.Ive bound the space drag to buttons in the Advanced Settings old controller ui and my space drag option on left and right hand is selected. Go to SteamVR settings and go to the Controller section. How to get OVR Advanced Settings play space drag to work in VRChat Ive followed like 3 different videos and none of them work.If "Comfort Zone" is any number other than 0, make it so. Go to "Motion" and enable Space Drag for left and right hands.For those unfamiliar, OVR Advanced Settings. The newest version of OVR Advanced Settings includes the option for Space Dragging and Space Fixing, which are similar to how playspace mover works in a way. A major update to OVR Advanced Settings adds redirected walking to steer you toward the center of your play space and away from the edges of your room. It requires messing around with settings and controller bindings in the SteamVR menu and OVR Advanced Settings tab. ![]() In the meanwhile, there is another way to get playspace to work. Open Build Settings window and follow this guide to set appropriate settings and upload rift application, linked here 3.Three ways of developing: Unity, Unreal, and Native (Largely the same between Quest and the Rift S) Unity. However for naelstrof's playspace mover it still remains a problem. For now, you’ll only need to prepare a small areaprobably around 1.5x1.5 metersto be VR-safe while sitting or standing with the Rift on your head. It turns out that for people using vive trackers whilst running hybrid setups with Oculus equipment, the newest version of Space Calibrator will fix calibration issues and return it to normal. ![]() ![]() Setup email campaigns on “Acme Company” audiences that are triggered on the creation of a tag. Want more automation resources sent to your inbox? Join our newsletter. Stagger out reminders over a period of time in case they don’t sign up on the earlier emails.Release access link to your mobile/web application.Break them into cohorts (by social behavior, occupation, persona, etc.).We will begin with an example where an audience is live in Mailchimp (here, Acme Company) and you want to do the following, We can also analyze important metrics such as conversion rates, cohort sizes, and backlogs easily. Lucky for us, our friends at Airtable have helped us build a data management and analysis tool that has the powers of Excel with all the pop you can imagine! With Zapier in the mix, we can now manage our entire waitlist on Airtable and deliver emails with the click of a button. However, mapping out customer journeys for driving app registrations and marketing on Mailchimp is either too tedious or expensive for your 5 person garage startup right now. To get started on emails, you likely want to set up a Mailchimp Audience with all your signups from the website. What more? You can personalize emails to better understand your customer’s needs and behaviours. It's an incredible strategy that can even help you nail your product-market fit. With Zapier, you can do more than just connect your apps - you can automate entire processes from beginning to end Check out the following list of triggers and actions you can use with SQL Server, Airtable, and Mailchimp. ![]() I don’t want to manage user data from the Email Marketing solution (e.g., MailChimp, etc.), so this seems to be the only solution in that vein.Setting up a waitlist offers some great advantages as you build alongside your very first believers. Do even more with SQL Server + Airtable + Mailchimp. If Airtable could do these things instead of MailChimp, then I believe we could make Airtable the “one place” for creating and editing data. Is there a Email Marketing solution other than MailChimp that does allow for two-way sync? We could then use this app to send our newsletters, but manage the lists from Airtable.Ģ) Is there a good way to move all of these functions to Airtable? This would include “subscribe forms” embedded in our website, and “unsubscribe links” at the bottom of our newsletters, which are curently handled by MailChimp.With Zapier, you can do more than just connect your apps - you can automate entire processes from. Do you know of other ways to do this? For example: Do even more with Airtable + Mailchimp + Mixpanel. We are established in Airtable for many areas of our operations, but we need a good option to integrate our contact lists from Airtable with an Email Marketing solution. Perhaps it’s worth “zooming out” on the problem if there’s not a good way to accomplish that specifically: It makes sense that a two way sync could be complicated. As of today’s writing, Outfunnel can do most but not all of this (like adding un/subscribes to Airtable). If you know of a fix for this with an email marketing program other than MailChimp, please let me know. I’d rather pay a small fee per month for an established app to do this than build it in Zapier/Make, but either way is fine if it works. ![]() With Zapier, you can do more than just connect your apps - you can automate entire processes from. Do even more with Airtable + Mailchimp + MoonClerk. With Zapier, you can do more than just connect your apps - you can automate entire processes from beginning to end Check out the following list of triggers and actions you can use with Airtable, Mailchimp, and Discord.
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